Binding and degradation of soluble immunoglobulin aggregates by mouse mononuclear phagocytes--stimulation by colony-stimulating factor.
نویسندگان
چکیده
منابع مشابه
Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1.
Secreted forms of macrophage colony-stimulating factor (M-CSF or CSF-1) are generated by proteolytic cleavage of membrane-bound glycoprotein precursors. Alternatively spliced transcripts of the human CSF-1 gene encode at least two different transmembrane precursors that are differentially processed in mammalian expression systems. The larger precursor rapidly undergoes proteolysis to yield the ...
متن کاملInhibition of colony-stimulating factor-1 activity by monoclonal antibodies to the human CSF-1 receptor.
Four of 12 monoclonal antibodies (MoAbs) directed to different epitopes in the extracellular domain of the human colony-stimulating factor-1 receptor (CSF-1R, the c-fms proto-oncogene product) specifically inhibit CSF-1 binding to receptor-bearing cells. All four antibodies abrogated CSF-1-dependent colony formation by human bone marrow-derived macrophage precursors and by mouse NIH-3T3 cells e...
متن کاملReceptor-mediated binding and internalization of colony-stimulating factor (CSF-1) by mouse peritoneal exudate macrophages.
Colony-stimulating factor (CSF-1) purified from L-cell-conditioned medium is a haemopoietic growth factor that specifically stimulates the proliferation and differentiation of mononuclear phagocytes. Using radioactively labelled CSF-1 [( 125I]CSF-1), the presence of specific CSF-1 receptor has been identified in the cells of the mononuclear phagocytic series and their precursors only. To determ...
متن کاملIn vitro proliferation of mononuclear phagocytes from murine and human bone marrow.
Techniques for liquid culture of proliferating mononuclear phagocytes from bone marrow of mice and men are described. Mouse bone marrow must be cultured in the presence of colony-stimulating factor, whereas proliferation of human mononuclear phagocytes occurred in medium with 50% serum but without colony-stimulating factor. The number of mononuclear phagocytes that can be determined in mouse bo...
متن کاملActivation of neutrophils by soluble and insoluble immunoglobulin aggregates from synovial fluid of patients with rheumatoid arthritis.
OBJECTIVES Previous work has shown that synovial fluid isolated from patients with active rheumatoid arthritis contains soluble (not sedimented by centrifugation at 11,600 g for two minutes) and insoluble (sedimented by centrifugation at 11,600 g for two minutes) immunoglobulin aggregates that are capable of activating reactive oxidant production by bloodstream neutrophils. The purpose of this ...
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ورودعنوان ژورنال:
- Cellular immunology
دوره 73 1 شماره
صفحات -
تاریخ انتشار 1982